If you are coming from St. Louis, you might come south on Route 3 (the Great River Road!)
and you’ll intersect with Route 149 to travel east to Murphysboro and Carbondale.
Or you might want to travel east on Interstate 64, get off at exit #50 for Nashville (Illinois) and head south on
Route 127 to Murphysboro and Carbondale.
Coming from the north or south? You’re probably planning to arrive via interstate 57,
so just jump off at Exit #54 for Carbondale!